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Where Ancient Ears Meet Modern Aging Science

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dr Karunia Valeriani Japar

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Keywords: Auriculotherapy, Longevity Medicine, Ear Seeding, Autonomic Regulation, Metabolic Regulation, Integrative Aging Wellness

Introduction

Longevity medicine emphasizes interventions that extend health span by addressing the underlying biological processes of aging, including cellular senescence, mitochondrial dysfunction, chronic inflammation, and neuroendocrine imbalance, all of which contribute to physiological decline and age-related diseases. Modern approaches to longevity integrate nutritional pharmacologic, behavioral, and bioelectronic methods to enhance resilience and delay biological aging.

Parallel to these scientific advances, Traditional Chinese Medicine (TCM) has long conceptualized health as the harmonious flow of Qi, the vital energy circulating through the body’s meridian system, Disruption of this energetic flow is believed to manifest as physical or emotional imbalance. Among TCM modalities, auriculotherapy or ear seeding represents a microsystem approach that maps somatic and visceral organs onto the auricle. Stimulation of specific auricular points, traditionally performed using vaccaria seeds, magnetic beads, or metallic pellets, is thought to restore systemic balance and support the body’s innate self-regulatory mechanisms.

Recent research has begun translating these traditional concepts into neurophysiological mechanisms the auricle is richly innervated by branches of the vagus, trigeminal and glossopharyngeal nerves, providing direct access to central autonomic and limbic circuits. Stimulation of vagal afferents through auricular acupoints has been shown to influence parasympathetic tone, heart rate variability, stress modulation, and even metabolic regulation, all of which are closely tied to the biology of healthy aging.

This convergence of ancient practice and contemporary science suggests that auriculotherapy may serve as a non-invasive neuromodulatory approach in modern longevity medicine. By influencing autonomic balance, reducing allostatic load, and modulating metabolic and inflammatory pathways, ear seeding presents a promising adjunct within preventive and restorative health strategies aimed at extending health span and improving overall vitality.

Theoretical Background: Ear Seeding and the Auricular Microsystem

Auriculotherapy is grounded in the concept that the external ear contains a somatotopic representation of the entire body, with discrete auricular zones corresponding to musculoskeletal regions, visceral organs, and neuroendocrine functions. Experimental work has provided support for this model, demonstrating reproducible mappings between specific auricular areas and peripheral body sites, and describing an inverted “fetal” or homunculus-like projection on the auricle. Within this framework, ear seeding involves the application of vaccaria seeds, metal pellets, or similar stimuli to defined acupoints with the aim of normalizing disturbed organ-related reflex zones and restoring energetic and functional balance [1,2,3].

From a biomedical perspective, these traditional maps can be interpreted through the detailed innervation of the auricle, particularly via the auricular branch of the vagus nerve (ABVN), as well as contributions from the trigeminal and cervical plexus. The ABVN provides a direct afferent pathway from auricular regions such as the cymba conchae to central autonomic networks in the nucleus tractus solitarius and related brainstem structures, which are critically involved in cardiovascular, endocrine, and inflammatory regulation. Transcutaneous stimulation of these vagal afferents has been shown to increase parasympathetic activity, enhance heart rate variability, and modulate stress-related autonomic imbalance, parameters closely linked to cardiometabolic risk and aging biology [4,5,6,7,8].

Figure 1. Hypothesis on the mechanism of auricular acupuncture for analgesia [4]

In addition, auricular vagus nerve stimulation appears to engage the cholinergic anti-inflammatory pathway, attenuating pro‑inflammatory cytokine release and influencing metabolic homeostasis via neuroimmune reflexes. Emerging data also suggest downstream effects on gut–brain and brain–immune axes, including alterations in gut microbiota composition and lipid and bile acid metabolism, further connecting auricular stimulation to systemic metabolic regulation. Together, these findings provide a mechanistic bridge between the traditional auricular microsystem model and contemporary understandings of neurovisceral integration, offering a plausible rationale for incorporating ear seeding into longevity- and metabolism-focused clinical frameworks [8,9,10].

Mechanistic Connections to Longevity and Metabolic Health

Ear seeding, through stimulation of auricular vagal afferents, is posited to influence several biological systems that are central to aging trajectories and metabolic homeostasis. These mechanisms can be framed along key axes relevant to longevity medicine: autonomic regulation, stress system modulation, inflammatory control, and sleep–circadian integrity [11,12,13].

Autonomic Regulation and Metabolic Homeostasis

Activation of the auricular branch of the vagus nerve via transcutaneous or acupressure-based stimulation has been shown to shift autonomic balance toward enhanced parasympathetic tone and improved heart rate variability, reflecting greater adaptive capacity of the cardiovascular and autonomic systems. Vagal efferent signalling influences hepatic glucose production, pancreatic insulin secretion, and peripheral insulin sensitivity, with auricular vagus nerve stimulation demonstrating reductions in blood glucose, improved glucose tolerance, and modulation of glycolipid metabolism in both animal models and early clinical studies. At the cellular level, vagus nerve stimulation appears to support mitochondrial bioenergetics through activation of AMP‑activated protein kinase pathways, increased mitochondrial biogenesis, and enhanced oxidative phosphorylation, which are all relevant to slowing functional decline and metabolic aging [11,12,14,15].

  • Stress Axis Modulation and HPA Balance

Chronic activation of the hypothalamic–pituitary–adrenal (HPA) axis, with sustained elevations in cortisol, is associated with visceral adiposity, insulin resistance, neurodegeneration, and accelerated cellular aging. Auricular acupuncture and auricular acupressure protocols have been reported to reduce salivary cortisol levels and improve indices of HPA regulation, suggesting a down‑modulation of stress system hyperactivity. These effects are thought to be mediated by vagal afferent input to brainstem and hypothalamic nuclei, modulating corticotropin‑releasing factor output and downstream autonomic–endocrine responses. By dampening chronic stress signalling, ear-focused interventions may help lower allostatic load, a core target in longevity frameworks that emphasize preservation of neuroendocrine flexibility over the lifespan [13,16,17,18,19].

Inflammatory Control and “Inflammaging”

Low-grade, persistent inflammation, “inflammaging” is a hallmark of aging and a share pathway linking metabolic disease, cardiovascular pathology, and neurodegeneration. Auricular vagus nerve stimulation engages the cholinergic anti-inflammatory pathway, wherein acetylcholine released via vagal–splenic circuits binds to α7 nicotinic receptors on macrophages, suppressing the production of pro-inflammatory cytokines such as tumor necrosis factor‑α and interleukin‑6. Clinical and perioperative studies of auricular or cervical vagus stimulation have reported reductions in circulating inflammatory markers, including interleukin‑6 and C‑reactive protein, alongside improved clinical outcomes in inflammatory states. Through attenuation of these cytokine pathways, ear seeding–based neuromodulation may contribute to slowing inflammatory damage to vascular, metabolic, and neural tissues over time [18,20,21].

Sleep, Circadian Rhythms, and Neurorestoration

Adequate sleep and robust circadian rhythms are critical determinants of insulin sensitivity, neuroplasticity, and cellular repair processes, and their disruption is tightly linked to metabolic dysfunction and accelerated aging. Studies in older adults with chronic insomnia and comorbid conditions suggest that transcutaneous auricular vagus nerve stimulation can improve sleep quality, modulate intestinal inflammation, and rebalance central neurotransmitter systems implicated in arousal and mood regulation. Vagal modulation has also been associated with changes in melatonin signalling and gut–brain axis function, which may further influence circadian alignment and nocturnal metabolic regulation. By supporting restorative sleep and circadian integrity, auricular stimulation potentially reinforces the physiological “recovery window” necessary for DNA repair, synaptic remodelling, and metabolic recalibration central to healthy aging [15,22].

Taken together, these interconnected mechanisms, autonomic optimization, HPA axis regulation, anti-inflammatory signalling, and sleep-circadian improvement directly address core pillars of longevity, including stress resilience, metabolic optimization, and reduction of cumulative biological wear. Within this framework, ear seeding can be conceptualized as a low-risk neuromodulatory adjunct that targets upstream regulatory networks rather than isolated endpoints, aligning well with systems-oriented approaches in contemporary longevity and metabolic medicine [11,12,13].

Clinical and Empirical Evidence

Stress, Anxiety, and Sleep Quality

Multiple randomized controlled trials and clinical studies have documented the effects of auricular acupuncture and acupressure on psychological stress, anxiety, and sleep disturbances. In a randomized trial involving adults with depression-related insomnia, participants receiving specific auricular acupuncture showed significant improvements in Pittsburgh Sleep Quality Index scores at four and six weeks compared to non-specific control interventions. Case reports of auricular acupuncture for COVID-19-associated persistent insomnia and anxiety demonstrated substantial reductions in both Insomnia Severity Index and Hamilton Anxiety Scale scores, with sustained remission at six-month follow-up. A quasi-experimental study in healthcare professionals treated with auricular laser acupuncture reported statistically significant reductions in state anxiety, stress, and sleep latency, alongside improvements in fatigue, with effect sizes ranging from small to medium. A separate randomized trial in military beneficiaries with chronic pain and insomnia showed that a standardized auricular acupuncture protocol yielded significant within-group and between-group improvements in insomnia severity compared to usual care [24,25,26].

Autonomic Modulation and Heart Rate Variability

Heart rate variability, a key marker of autonomic balance and cardiovascular resilience, has been investigated as an outcome of auricular stimulation in several studies. A pilot study examining auricular acupressure at the sympathetic point demonstrated significant reductions in heart rate and increases in high-frequency power, a marker of parasympathetic activity during and following stimulation, with no changes in respiratory rate or low-frequency power. A separate study in hospitalized patients undergoing auriculotherapy found significant increases in standard deviation of normal-to-normal intervals, total power, and high-frequency power, indicating enhanced total autonomic activity with preferential augmentation of parasympathetic tone. A meta-analysis of acupuncture interventions, including auricular protocols, concluded that real acupuncture had a superior effect over sham in increasing parasympathetic tone, supporting the hypothesis of vagally mediated autonomic modulation [27,28,29].

Metabolic Regulation, Appetite Control, and Obesity

Auricular acupuncture has been evaluated in the context of obesity and metabolic syndrome, with measurable effects on body composition, appetite, and glycemic parameters. A prospective study using auricular acupuncture with beads reported a significant weight loss of 3.57% over the intervention period, with suppression of postprandial blood glucose increases most evident 90 to 105 minutes after meals, suggesting modulation of insulin secretion and glycemic response. A follow-up component of that study showed sustained weight loss six months post-intervention, attributed to possible leptin sensitivity resetting and dietary behavioural changes. A systematic review and meta-analysis of auricular acupoint stimulation in overweight and obese adults demonstrated significant reductions in body weight, body mass index, body fat percentage, and waist circumference, with longer treatment durations yielding greater anthropometric benefits. Mechanistic analyses indicated that auricular acupuncture influences appetite-regulating hormones, including ghrelin and leptin, as well as insulin resistance and inflammatory markers associated with metabolic dysfunction [30,31,32].

Pain and Inflammation Reduction

Auricular acupuncture protocols have been shown to reduce both chronic pain severity and pain interference, likely through neural reflex pathways and anti-inflammatory mechanisms. In a randomized trial of military beneficiaries with chronic pain, participants receiving auricular acupuncture experienced significant within-group and between-group reductions in pain severity and interference scores compared to usual care over an eight-day period. Though the neural and neuroimmune mechanisms underlying these effects are still under investigation, the engagement of vagal afferents and the cholinergic anti-inflammatory pathway offer plausible explanations for auriculotherapy’s pain-modulating and inflammation-reducing properties [12,13,24].

Despite these encouraging findings, the field faces methodological limitations, including variability in acupoint selection, stimulation techniques, treatment durations, and small sample sizes in many studies. The heterogeneity in outcomes and the lack of standardized protocols reduce the generalizability of findings and highlight the need for larger, well-controlled, mechanistic trials. Nonetheless, the convergence of evidence across psychological, autonomic, metabolic, and inflammatory domains suggests that auriculotherapy may serve as a safe, low-risk adjunctive modality within integrative longevity programs, complementing nutritional optimization, pharmacologic interventions, and behavioural health strategies aimed at extending health span and reducing biological aging [23,24,31,33].

Integrative Application in Longevity Medicine

As longevity medicine increasingly integrates digital health technologies, wearable biosensors, and personalized preventive frameworks, auricular acupuncture and ear seeding present an opportunity to expand the therapeutic repertoire with a non-invasive, adaptable biomodulatory intervention. The convergence of traditional auriculotherapy with modern health technology platforms enables real-time, individualized monitoring and treatment optimization, positioning ear seeding as a complementary modality within comprehensive longevity and metabolic health programs [34,35,36,37].

Digital Integration and Personalized Monitoring

Recent developments in smartphone applications and wearable devices have demonstrated the feasibility of integrating auricular acupressure into self-management protocols for metabolic and stress-related conditions. A randomized controlled trial examining self-administered auricular acupressure integrated with a smartphone app for weight reduction showed that digital reminders, compliance tracking, and educational content significantly enhanced adherence and outcomes compared to auricular acupressure alone. The app utilized daily notifications, video demonstrations of proper stimulation technique, and a decision-tree algorithm to personalize reminder frequency based on user compliance, thereby supporting self-regulation and behavioural modification. Similarly, a smartphone-guided auricular point acupressure intervention for chronic musculoskeletal pain resulted in clinically meaningful reductions in pain intensity, pain interference, and disability over a four-week period, with high user satisfaction and feasibility ratings. These findings suggest that technology-assisted auriculotherapy can empower patients to deliver self-care interventions with minimal professional supervision while maintaining therapeutic fidelity [34,37,38].

Extending this model to longevity practice, ear seeding protocols could be coupled with wearable biosensors that track heart rate variability, sleep architecture, glucose trends, and autonomic tone. For instance, continuous HRV monitoring via smartwatch could identify periods of low parasympathetic activity or elevated sympathetic dominance, triggering personalized prompts to apply auricular acupressure at vagal-modulating points such as the cymba conchae or tragus. Artificial intelligence, driven platforms could further analyse longitudinal patterns  in biometric data and recommend individualized acupoint selections tailored to each user’s metabolic, stress, and circadian profiles, enabling precision-oriented autonomic interventions within digital longevity ecosystems [27,29,35,39].

Targeted Acupoint Protocols and Longevity Domains

Within Traditional Chinese Medicine, specific auricular acupoints correspond to functional and energetic systems relevant to aging and metabolic wellness, including Shenmen (spirit gate, associated with calming the mind and autonomic balance),  Endocrine (hormonal regulation), Shen (kidney, linked to vitality and essence), , Pizhixia (subcortex, modulating cortical excitation and inhibition), and organ-specific points such as Xin (heart) and Gan (liver). These points have been empirically selected in clinical trials targeting insomnia, stress, metabolic disorders, and chronic pain, with outcomes demonstrating improvements in sleep quality, neuroendocrine biomarkers, and glycemic control [40,41,42].

In an integrative longevity framework, protocols could be tailored according to individualized health goals and biological vulnerabilities. For example, individuals with elevated cortisol, poor sleep efficiency, and low HRV might receive a protocol emphasizing Shenmen, Endocrine, and Pizhixia to target HPA axis regulation and circadian rhythm restoration. Those with metabolic syndrome or prediabetes could utilize points associated with appetite regulation, glucose homeostasis, and inflammation modulation, such as Shen,Gan and hunger-related microsystem zones, informed by previous studies demonstrating reductions in body weight, postprandial glucose, and insulin resistance markers. By aligning acupoint selection with evidence-based outcomes and individual phenotypic data, auriculotherapy becomes a targeted, precision-informed adjunct rather than a generalized intervention [30,31,35,36,37,40,].

Position within Evidence-Informed Integrative Care Models

The integration of ear seeding into longevity practice aligns with broader movements toward multimodal, systems-based preventive medicine that combines pharmacologic, nutritional, behavioural, and bioelectronic interventions. Auriculotherapy is now recognized within mainstream healthcare institutions, including military and NATO medical systems, where standardized auricular acupuncture protocols have been deployed for pain management, stress reduction, and operational resilience. In civilian healthcare, auricular acupuncture is increasingly incorporated into integrative wellness centers, physical therapy clinics, and hospital-based complementary medicine programs, supported by emerging evidence and technology-enabled delivery models [35,43].

Within a longevity-focused care pathway, ear seeding could serve as a first-line or adjunctive intervention for stress modulation, sleep optimization, and metabolic fine-tuning, particularly in individuals seeking non-pharmacologic options or those with contraindications to conventional therapies. When combined with continuous glucose monitoring, HRV-guided breathing exercises, personalized nutrition plans, and pharmacologic senolytic or metabolic agents, auriculotherapy contributes to a holistic, data-informed strategy aimed at reducing biological age, optimizing health span, and supporting resilience across multiple physiological domains. As digital therapeutics and AI-powered personalization tools continue to evolve, the potential for auriculotherapy to become a scalable, evidence-based component of precision longevity medicine becomes increasingly tangible [35,36,37,43,44].

Challenges and Future Directions

Current evidence for auriculotherapy in longevity medicine is constrained by several limitations, including non-standardized auricular maps, heterogeneous stimulation parameters, and the predominance of small, underpowered trials with variable control conditions. These factors reduce reproducibility, complicate meta-analytic synthesis, and make it difficult to define indication-specific, evidence-based protocols for autonomic, metabolic, or inflammatory outcomes [4,45,46,47].

Future work should prioritize rigorous neurophysiological mapping of auricular stimulation, using imaging and autonomic biomarkers to clarify site-specific effects and metabolic correlates, alongside larger longitudinal studies that assess impacts on biological aging markers such as epigenetic clocks, mitochondrial function, and heart rate variability trajectories. Integrating artificial intelligence and digital health platforms could enable pattern recognition between biometric data and specific acupoint protocols, supporting adaptive, personalized ear seeding strategies within precision longevity frameworks and deepening understanding of how traditional energetic concepts intersect with modern aging biology [4,45,46,47].

Conclusion

Ear seeding, grounded in the principles of Traditional Chinese Medicine, offers a distinctive, minimally invasive approach to modulating neuro-visceral pathways that influence systemic homeostasis. Contemporary interpretations supported by physiological and neurobiological research suggest that auricular stimulation may engage autonomic and endocrine networks critical for metabolic regulation, stress resilience, and inflammatory control. These mechanisms align closely with the foundational objectives of longevity medicine, which seek to optimize adaptive capacity, reduce biological stressors, and sustain functional health across the lifespan.

By integrating ear seeding within evidence-informed longevity frameworks, clinicians and health practitioners can explore its potential as a complementary modality that supports autonomic balance and metabolic stability. Furthermore, this practice represents a meaningful convergence between ancient healing systems and modern biotechnological insight, an approach that values both energetic harmony and molecular precision. Advancing this field will require rigorous, interdisciplinary research to elucidate mechanistic links, optimize protocols, and validate long-term outcomes in aging and metabolic wellness.

Ultimately, bridging the wisdom of traditional medicine with the rigor of contemporary longevity science invites a more holistic and integrative understanding of human health. Such synthesis underscores the notion that extending health span is not solely the domain of biochemistry or technology, but also of restoring balance within physiology, lifestyle, and the subtle interactions between mind and body.

Reference

  1. Oleson TD, Kroening RJ, Bresler DE. An experimental evaluation of auricular diagnosis: The somatotopic mapping of musculoskeletal pain at ear acupuncture points. Pain. 1980 Apr;8(2):217–29.
  2. Round R, Litscher G, Bahr F. Auricular Acupuncture with Laser. Evidence-Based Complementary and Alternative Medicine. 2013;2013:1–22.
  3. Auricular Acupuncture as an Alternative Medicine [Internet]. Heraldopenaccess.us. 2017 [cited 2026 Feb 3]. Available from: https://www.heraldopenaccess.us/openaccess/auricular-acupuncture-as-an-alternative-medicine
  4. Guo K, Lu Y, Wang X, Duan Y, Li H, Gao F, et al. Multi-level exploration of auricular acupuncture: from traditional Chinese medicine theory to modern medical application. Frontiers in Neuroscience. 2024 Sep 23;18.
  5. Schiweck C, Mareike Aichholzer, Brandt E, Schneider M, Meyer K, Tirage Hamzehloiya, et al. The heart knows best: baseline heart rate variability as guide to transcutaneous auricular vagus nerve stimulation in depression. Translational Psychiatry. 2025 Dec 6;
  6. Weise D, Adamidis M, Rumpf JJ ., Fricke C, Classen J. P184. Heart rate variability and its modulation by auricular branch of vagus nerve stimulation in Parkinson’s disease. Clinical Neurophysiology. 2015 Aug;126(8):e165.
  7. Forte G, Favieri F, Leemhuis E, Cristina M, Anna Maria Giannini, Luigi De Gennaro, et al. Ear your heart: transcutaneous auricular vagus nerve stimulation on heart rate variability in healthy young participants. 2022 Nov 21;10:e14447–7.
  8. de Moraes TL, Costa FO, Cabral DG, Fernandes DM, Sangaleti CT, Dalboni MA, et al. Brief periods of transcutaneous auricular vagus nerve stimulation improve autonomic balance and alter circulating monocytes and endothelial cells in patients with metabolic syndrome: a pilot study. Bioelectronic Medicine [Internet]. 2023 Mar 31 [cited 2023 Dec 4];9(1):7. Available from: https://pubmed.ncbi.nlm.nih.gov/36998060/
  9. Han R, Peng Z, Zhuo M, Song Y, Liu Y, Zhang X, et al. Cholinergic reflex control of inflammation: mechanistic and translational advances in transcutaneous auricular vagus nerve stimulation across rheumatic, metabolic, and postoperative disorders. Frontiers in Immunology. 2026 Jan 21;16.
  10. Zhang X, He X, Zhao Y, Zou Q, Liang Y, Zhang J, et al. Transcutaneous auricular vagus nerve stimulation regulates gut microbiota mediated peripheral inflammation and metabolic disorders to suppress depressive-like behaviors in CUMS rats. Frontiers in microbiology [Internet]. 2025;16:1576686. Available from: https://pubmed.ncbi.nlm.nih.gov/40809052/
  11. Zou N, Zhou Q, Zhang Y, Xin C, Wang Y, Claire-Marie R, et al. Transcutaneous auricular vagus nerve stimulation as a novel therapy connecting the central and peripheral systems: a review. International Journal of Surgery [Internet]. 2024 May 9;110(8):4993–5006. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC11326027/
  12. Kaniusas E, Kampusch S, Tittgemeyer M, Panetsos F, Gines RF, Papa M, et al. Current Directions in the Auricular Vagus Nerve Stimulation I – A Physiological Perspective. Frontiers in Neuroscience. 2019 Aug 9;13.
  13. Liu FJ, Wu J, Gong LJ, Yang HS, Chen H. Non-invasive vagus nerve stimulation in anti-inflammatory therapy: mechanistic insights and future perspectives. Frontiers in Neuroscience. 2024 Nov 13;18.
  14. Bencharunan Samniang, Krekwit Shinlapawittayatorn, Titikorn Chunchai, Wanpitak Pongkan, Sirinart Kumfu, Chattipakorn SC, et al. Vagus Nerve Stimulation Improves Cardiac Function by Preventing Mitochondrial Dysfunction in Obese-Insulin Resistant Rats. Scientific Reports. 2016 Feb 1;6(1).
  15. Zhang Y, Zou N, Xin C, Wang Y, Zhang Z, Rong P, et al. Transcutaneous auricular vagal nerve stimulation modulates blood glucose in ZDF rats via intestinal melatonin receptors and melatonin secretion. Frontiers in Neuroscience. 2024 Nov 5;18.
  16. Bijan PIRNIA, Negin MOHAMMADZADEH BAZARGAN, Mostafa HAMDIEH, Kambiz PIRNIA, Parastoo MALEKANMEHR, MALEKI F, et al. The Effectiveness of Auricular Acupuncture on the Levels of Cortisol in a Depressed Patient. Iranian Journal of Public Health [Internet]. 2019 Sep [cited 2026 Feb 3];48(9):1748. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC6825666/
  17. Kuo SY, Tsai SH, Chen SL, Tzeng YL. Auricular acupressure relieves anxiety and fatigue, and reduces cortisol levels in post-caesarean section women: A single-blind, randomised controlled study. International Journal of Nursing Studies. 2016 Jan;53:17–26.
  18. Tyler WJ. Transcutaneous Auricular Vagus Nerve Stimulation for Treating Emotional Dysregulation and Inflammation in Common Neuropsychiatric Disorders. Brain sciences [Internet]. 2025;16(1):8. Available from: https://pubmed.ncbi.nlm.nih.gov/41594729/
  19. Pirnia B, Pirnia K, Haghighat S, Malekanmehr P, Zahiroddin A. The Effectiveness of Acupuncture on Cortisol Levels in a Prostate-Carcinoma Patient under Androgen Deprivation Therapy with Dysthymic Syndrome: A Single-case Experimental Design. Original Article Middle East Journal of Cancer [Internet]. 2015;(3):237–42. Available from: https://mejc.sums.ac.ir/article_46430_6a8a77e88d3611af49b39d5ee53bf35c.pdf
  20. Salama M, Akan A, Mueller MR. Transcutaneous Stimulation of Auricular Branch of the Vagus Nerve Attenuates the Acute Inflammatory Response After Lung Lobectomy. World Journal of Surgery. 2020 May 1;44(9):3167–74.
  21. Liu L, Lou S, Fu D, Ji P, Xia P, Shuang S, et al. Neuro-immune interactions: Exploring the anti-inflammatory role of the vagus nerve. International Immunopharmacology [Internet]. 2025 May 28;159:114941. Available from: https://www.sciencedirect.com/science/article/pii/S1567576925009312?via%3Dihub#s0095
  22. Zhou H, Tang X, Wang D, Huang Z, Zeng Y, Liu S, et al. Neuroregulatory and clinical efficacy of auricular vagus nerve stimulation in elderly patients with chronic insomnia comorbid with functional dyspepsia: protocol for a randomized controlled trial. Frontiers in Medicine. 2025 Mar 18;12.
  23. Silva LR, Toledo LV, Siman AG, Miranda, Clara M, Rodrigues YM, et al. Effectiveness of auricular laser acupuncture on anxiety, stress, sleep quality, fatigue and muscle tension of Psychosocial Care Center professionals: a quasi-experimental pilot study. Revista Brasileira de Enfermagem [Internet]. 2025 Jan 1;78(3). Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC12252929/
  24. Garner BK, Hopkinson SG, Ketz AK, Landis CA, Trego LL. Auricular Acupuncture for Chronic Pain and Insomnia: A Randomized Clinical Trial. Medical Acupuncture. 2018 Oct;30(5):262–72.
  25. Hu H, Cheng Y, Fang L, Yang L, Li X. Auricular acupuncture for persistent insomnia and anxiety associated with COVID-19: a case report. Frontiers in Neurology [Internet]. 2023 Sep 22;14. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10560090/pdf/fneur-14-1239385.pdf
  26. Silotto AEMR, Heps A, Rodrigues DMO, Pacheco PH de M, Sanches NMP, Schveitzer MC, et al. Efficacy of auricular acupuncture on sleep quality among individuals with depression: a clinical trial. Revista de saude publica [Internet]. 2025 Winter;59:e27. Available from: https://pubmed.ncbi.nlm.nih.gov/41172491/
  27. Trinh DTT, Nguyen QCT, Bui MMP, Nguyen VD, Thai KM. Heart Rate Variability during Auricular Acupressure at Heart Point in Healthy Volunteers: A Pilot Study. Evidence-Based Complementary and Alternative Medicine [Internet]. 2022 Apr 25 [cited 2023 Apr 18];2022:e1019029. Available from: https://www.hindawi.com/journals/ecam/2022/1019029/
  28. Hamvas Sz, Hegyi P, Kiss Sz, Lohner Sz, McQueen D, Havasi M. Acupuncture increases parasympathetic tone, modulating HRV − Systematic review and meta-analysis. Complementary Therapies in Medicine. 2023 Mar;72:102905.
  29. Chen CC, Chen SP, Hsu CH. Heart Rate Variability Subsequent to Auriculotherapy Among Individuals Afflicted by Major Burn Scars. Annals of Plastic Surgery [Internet]. 2025 Feb 25 [cited 2026 Feb 3];94(3S):S63–8. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC11875405/
  30. Fujimoto T, Kobayashi H, Hataoka T, Taniguchi K, Miura K. Auricular Acupuncture with Beads Supports Sustained Weight Loss. OBM Integrative and Complementary Medicine. 2020 Dec 9;5(4).
  31. Yeh TL, Chen HH, Pai TP, Liu SJ, Wu SL, Sun FJ, et al. The Effect of Auricular Acupoint Stimulation in Overweight and Obese Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Evidence-based Complementary and Alternative Medicine. 2017 Jan 1;2017:1–16.
  32. Yahagi T. The Effectiveness of Auricular Acupuncture Therapy in Treatment of Obesity: Literature Review A RESEARCH PROJECT SUBMITTED IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE Doctor of Acupuncture and Oriental Medicine ANAHEIM, CALIFORNIA [Internet]. 2018 [cited 2026 Feb 3]. Available from: https://app.southbaylo.net/c1/library/uploads/daom/125 Tamie Yahagi.pdf
  33. Bergdahl L, Broman JE ., Berman AH, Haglund K, von Knorring L, Markström A. Auricular Acupuncture and Cognitive Behavioural Therapy for Insomnia: A Randomised Controlled Study. Sleep Disorders [Internet]. 2016 [cited 2020 Jan 4];2016:1–7. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876000/
  34. Kawi J, Yeh CH, Li M, Caswell K, Mazraani M, Lukkahatai N, et al. Auricular Point Acupressure Smartphone Application to Manage Chronic Musculoskeletal Pain: A Longitudinal, One-Group, Open Pilot Trial. Global Advances in Health and Medicine [Internet]. 2021 Jan [cited 2026 Feb 3];10. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC7876936/
  35. and R. Technology Landscape, Trends and Opportunities in Acupuncture Market [Internet]. Researchandmarkets.com. 2025 [cited 2026 Feb 3]. Available from: https://www.researchandmarkets.com/reports/6056638/technology-landscape-trends-opportunities-in
  36. Zhang E, Litscher G. An Interview with Professor Gerhard Litscher: “How High-Tech and Digitalization Are Revolutionizing the Future of Acupuncture.” OBM Integrative and Complementary Medicine [Internet]. 2024 Sep 11 [cited 2026 Feb 3];09(03):1–7. Available from: https://www.lidsen.com/journals/icm/icm-09-03-050
  37. Suen L, Wang W, Cheng KKY, Chua MCH, Yeung JWF, Koh WK, et al. Self-Administered Auricular Acupressure Integrated With a Smartphone App for Weight Reduction: Randomized Feasibility Trial. JMIR mHealth and uHealth. 2019 May 29;7(5):e14386.
  38. gov. 2026 [cited 2026 Feb 3]. Available from: https://clinicaltrials.gov/study/NCT06744933
  39. Zhang E, Litscher G. An Interview with Professor Gerhard Litscher: “How High-Tech and Digitalization Are Revolutionizing the Future of Acupuncture.” OBM Integrative and Complementary Medicine [Internet]. 2024 Sep 11;09(03):1–7. Available from: https://www.lidsen.com/journals/icm/icm-09-03-050
  40. Zhang L, Liu Y. Combined Auricular Acupoint Pressing and Intradermal Acupuncture for Insomnia and Glycemic Control in Elderly Patients with Type 2 Diabetes: A Retrospective Study. Journal of Multidisciplinary Healthcare [Internet]. 2025 Nov [cited 2026 Feb 3];Volume 18:7647–57. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC12649788/
  41. Wang Y, Li X, Ji X, Wu J, Li J, Zheng W, et al. Adaptive Auricular Point Acupressure for Sleep Disturbance in Women with Breast Cancer: A Randomized Controlled Trial. Evidence-Based Complementary and Alternative Medicine [Internet]. 2022 Oct 31 [cited 2023 Mar 5];2022:e8637386. Available from: https://www.hindawi.com/journals/ecam/2022/8637386/
  42. Wang M, Li JL, Qin Y, Huang JF, Shi Y. Meta-analysis of ear acupoint therapy to treat sleep disorders in hemodialysis patients. TMR Integrative Medicine [Internet]. 2023 [cited 2026 Feb 3];7(0):e23022. Available from: https://www.tmrjournals.com/public/articlePDF/20230805/c81df7c961942edcb633a5659aeabcdb.pdf
  43. Southern Cross University. TC does ear seeding treat stress fatigue – Southern Cross University [Internet]. Scu.edu.au. 2025 [cited 2026 Feb 3]. Available from: https://www.scu.edu.au/news/2025/tc-does-ear-seeding-treat-stress-fatigue/
  44. Kim N, Keisuke Alexander Nakamura. Digital Therapeutics in Hearing Healthcare: Evidence-Based Review. Journal of audiology & otology. 2024 Jul 9;
  45. Verma N, Mudge J, Maïsha Kasole, Chen RC, Blanz SL, Trevathan JK, et al. Auricular Vagus Neuromodulation—A Systematic Review on Quality of Evidence and Clinical Effects. Frontiers in Neuroscience. 2021 Apr 30;15.
  46. Wang Y, Shi X, Efferth T, Shang D. Artificial intelligence-directed acupuncture: a review. Chinese Medicine. 2022 Jun 28;17(1).
  47. Hou GL, Dong BQ, Yu BX, Dai JY, Lin XX, Cheng ZZ. Artificial intelligence in acupuncture: bridging traditional knowledge and precision integrative medicine. Frontiers in Medicine. 2025 Jul 31;12.

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