Tag: Linoleic Acid
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Oxidized Linoleic Acid: The Hidden Driver of Modern Metabolic Crisis
Modern Western diets contain 20-30 times more linoleic acid than a century ago, primarily from processed seed oils. This dramatic shift has generated oxidized linoleic acid metabolites (OXLAMs) that trigger mitochondrial dysfunction, inflammatory cascades, and insulin resistance through distinct biochemical pathways. Unlike saturated fats that primarily activate ceramide-PKC pathways, linoleic acid promotes oxidative stress-induced metabolic…