Tag: Insulin Resistance
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Hyperglycemic Neurodegeneration: The Molecular Pathophysiology of Glucose-Induced Alzheimer’s Disease Risk
Elevated blood glucose levels have been increasingly recognized as a critical risk factor in the pathogenesis of Alzheimer’s disease, with mounting evidence linking metabolic dysregulation and impaired glucose metabolism to accelerated neurodegeneration and cognitive decline.
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Beyond Calories In, Calories Out: The Carbohydrate-Insulin Model as a Paradigm Shift for Obesity Prevention and Metabolic Health Optimization
The global obesity pandemic persists despite decades of caloric restriction approaches, suggesting fundamental limitations in current weight regulation paradigms. This review synthesizes emerging evidence supporting the carbohydrate-insulin model (CIM), which proposes that hormonal responses to high-glycemic carbohydrates drive fat storage and subsequently increase energy intake—reversing traditional causality assumptions. Clinical evidence demonstrates superior metabolic outcomes through…