Tag: Insulin Resistance
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The Statin Paradox: Balancing Cardiovascular Longevity with the Risks of Metabolic Dysregulation
Statins significantly reduce cardiovascular mortality but may paradoxically induce insulin resistance and diabetes, necessitating personalized prescribing to balance vascular benefits against metabolic risks for optimal long-term health outcomes.
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Migraine and Metabolism: How Insulin Resistance Fuels the Brain’s Energy Crisis
Emerging research reveals migraine as a metabolic disorder driven by insulin resistance and energy dysregulation, offering new pathways for prevention and personalized treatment beyond traditional symptom management.
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Water Fasting and Detoxification: Separating Scientific Evidence from Popular Claims
Water fasting’s detoxification claims lack scientific support. The liver and kidneys continuously eliminate toxins without fasting, while prolonged abstinence risks serious metabolic and electrolyte complications.
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What’s Hiding in Your Food? The Link Between Label Literacy, Hidden Sugars, and Long-Term Health
A guide to decoding nutrition labels, identifying hidden sugars in processed foods, and understanding their biochemical impacts on metabolic health, insulin resistance, and chronic disease prevention.
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The Randle Cycle and Metabolic Inflexibility: When Your Body’s Fuel-Switching System Breaks Down
Explore how disruption of the glucose-fatty acid cycle drives insulin resistance, type 2 diabetes, and cardiovascular disease—and discover evidence-based interventions including diet, exercise, and targeted therapies that can restore metabolic flexibility.
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Metabolic Flexibility and the Randle Cycle: Understanding Fuel Switching as the Foundation of Health and Prevention of Metabolic Disease
The maintenance of energy homeostasis in humans depends upon the remarkable capacity of the body to adaptively switch between available fuel sources, a feature defined as metabolic flexibility.
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Hyperglycemic Neurodegeneration: The Molecular Pathophysiology of Glucose-Induced Alzheimer’s Disease Risk
Elevated blood glucose levels have been increasingly recognized as a critical risk factor in the pathogenesis of Alzheimer’s disease, with mounting evidence linking metabolic dysregulation and impaired glucose metabolism to accelerated neurodegeneration and cognitive decline.
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Beyond Calories In, Calories Out: The Carbohydrate-Insulin Model as a Paradigm Shift for Obesity Prevention and Metabolic Health Optimization
The global obesity pandemic persists despite decades of caloric restriction approaches, suggesting fundamental limitations in current weight regulation paradigms. This review synthesizes emerging evidence supporting the carbohydrate-insulin model (CIM), which proposes that hormonal responses to high-glycemic carbohydrates drive fat storage and subsequently increase energy intake—reversing traditional causality assumptions. Clinical evidence demonstrates superior metabolic outcomes through…