Tag: Insulin
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Unraveling the Neurometabolic Architecture of Obesity: From Monogenic Syndromes to Polygenic Vulnerability and Hormonal Dysregulation
Fat accumulation results from disrupted hormonal signaling that fundamentally alters energy partitioning—the process determining whether calories are stored as fat or burned for energy, operating largely outside conscious control.
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Oxidized Linoleic Acid: The Hidden Driver of Modern Metabolic Crisis
Modern Western diets contain 20-30 times more linoleic acid than a century ago, primarily from processed seed oils. This dramatic shift has generated oxidized linoleic acid metabolites (OXLAMs) that trigger mitochondrial dysfunction, inflammatory cascades, and insulin resistance through distinct biochemical pathways. Unlike saturated fats that primarily activate ceramide-PKC pathways, linoleic acid promotes oxidative stress-induced metabolic…
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The Microbiota-Gut-Brain Axis: From Mechanistic Understanding to Precision Medicine Applications in Metabolic and Neuropsychiatric Disorders
This article examines bidirectional gut-brain communication through neural, immune, and metabolic pathways, highlighting therapeutic interventions including psychobiotics, dietary modifications, and fecal microbiota transplantation for treating depression, autism spectrum disorder, Parkinson’s disease, and metabolic dysfunction.
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Dyslipidemia Unmasked: A Functional Medicine Approach to Identifying and Reversing Its True Root Causes
Dyslipidemia extends far beyond cholesterol, often signaling deeper imbalances like insulin resistance, inflammation, and gut dysbiosis. Advanced biomarkers like ApoB, Lp(a), and hs-CRP uncover these root causes, enabling targeted, lifestyle-based interventions that offer more effective cardiovascular protection than traditional management alone.