Tag: Fatty Acids
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Oxidized Linoleic Acid: The Hidden Driver of Modern Metabolic Crisis
Modern Western diets contain 20-30 times more linoleic acid than a century ago, primarily from processed seed oils. This dramatic shift has generated oxidized linoleic acid metabolites (OXLAMs) that trigger mitochondrial dysfunction, inflammatory cascades, and insulin resistance through distinct biochemical pathways. Unlike saturated fats that primarily activate ceramide-PKC pathways, linoleic acid promotes oxidative stress-induced metabolic…
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Rethinking Saturated Fat: Why Decades of Dietary Dogma May Need a Modern Makeover
Contemporary evidence from high-quality trials challenges traditional saturated fat restrictions, revealing that cardiovascular outcomes depend more on what replaces saturated fat—and the food source—than absolute limits. The focus is shifting from rigid nutrient targets to holistic, food-based dietary patterns for heart health.